Document Detail

Antiosteoporotic activity of Dae-Bo-Won-Chun in ovariectomized rats.
MedLine Citation:
PMID:  11180524     Owner:  NLM     Status:  MEDLINE    
The preventive effect of the herbal formulation, "Dae-Bo-Won-Chun" (DBWC), on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. From light microscope analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in ovariectomized rats, whereas those of the same bone in sham-operated rats were composed of fine particles. The trabecular bone area and trabecular thickness in ovariectomized rats decreased by 50% from those in sham-operated rats, these decreases were completely inhibited by administration of DBWC at a concentration of 10 mg/kg per day for 7 weeks. The mechanical strength of the neck of the femur was decreased by ovariectomy, and this was significantly suppressed by the administration of DBWC. Serum phosphorus, alkaline phosphatase and thyroxine levels in ovariectomized rats increased compared with those in sham-operated rats, and increases were completely inhibited by the administration of DBWC. These results strongly suggest that DBWC is effective in preventing the development of bone loss induced by ovariectomy in rats.
H J Chae; J S Kang; J H Kim; C W Kim; S K Yoo; T Y Shin; B Choi; H M Kim; H R Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  15     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Department of Dental Pharmacology and Wonkwang Dental Research Institute, School of Dentistry, Iksan, Chonbuk 570-749, 570-749, South Korea.
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MeSH Terms
Disease Models, Animal
Drugs, Chinese Herbal / pharmacology*,  therapeutic use*
Femur / drug effects
Osteoporosis / prevention & control*
Plants, Medicinal*
Rats, Sprague-Dawley
Tibia / drug effects
Reg. No./Substance:
0/Drugs, Chinese Herbal

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