| Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. | |
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MedLine Citation:
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PMID: 20655993 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels. These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity. |
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Authors:
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Rahul Birari; Vishal Javia; Kamlesh Kumar Bhutani |
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Publication Detail:
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Type: Journal Article Date: 2010-07-23 |
Journal Detail:
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Title: Fitoterapia Volume: 81 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1129-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali 160062, Punjab, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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