| Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet. | |
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MedLine Citation:
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PMID: 19854381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Emerging evidence suggests that consumption or supplementation of foods rich in iso flavones may has a beneficial effect on obesity and glucose levels in animals and humans. It has been demonstrated that genistein, the main component of iso fl avones, could significantly reduce body weight and fat pad size. However, there is no evidence as to whether daidzein, which is also a main component of isoflavones, has the same effect. We hypothesize that LRXH609 (Dzd; a daidzein derivative) also has an antiobesity effect. In this study, we investigate the effects of Dzd on body weight, adipose tissue, blood, and liver lipid levels in obese mice fed a high-fat diet. Activities of pancreatic lipase and lipoprotein lipase, as well as lipolysis, were verified to clarify the potential mechanism of the daidzein. The results indicate that Dzd can significantly reduce body and fat pad weight and ameliorate the high-fat diet-induced hyperlipoidemia. We also found that Dzd inhibits the activity of pancreatic lipase and lipoprotein lipase in a dose-dependent manner, inhibits the differentiation of rat preadipocytes, and stimulates lipolysis by activating hormone-sensitive lipase. |
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Authors:
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Yongqi Guo; Guanzhong Wu; Xin Su; Hongxia Yang; Juan Zhang |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 29 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 656-63 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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drug effects Adipose Tissue / drug effects Animals Antilipemic Agents / pharmacology, therapeutic use* Body Weight / drug effects* Dietary Fats / administration & dosage, adverse effects Dose-Response Relationship, Drug Hyperlipidemias / drug therapy, metabolism Isoflavones / pharmacology, therapeutic use* Lipolysis / drug effects* Lipoprotein Lipase / antagonists & inhibitors Male Mice Mice, Inbred ICR Mice, Obese Obesity / drug therapy*, enzymology, metabolism Organ Size / drug effects Pancreas / enzymology Phytotherapy* Plant Extracts / pharmacology, therapeutic use* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Dietary Fats; 0/Isoflavones; 0/Plant Extracts; 486-66-8/daidzein; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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