Document Detail

Antiobesity Effects of Chinese Black Tea (Pu-erh Tea) Extract and Gallic Acid.
MedLine Citation:
PMID:  22508359     Owner:  NLM     Status:  In-Data-Review    
The antiobesity effects of Chinese black tea (Pu-erh tea) and of gallic acid (GA) were investigated using in vitro and in vivo assays. Chinese black tea extract (BTE) and GA inhibited pancreatic lipase activity in a dose-dependent manner in vitro; the IC(inhibitory concentration)(50) values were 101.6 and 9.2 µg/mL, respectively. Black tea extract (50, 100 mg/kg body weight (b.w.)) and GA (15, 45 mg/kg b.w.) significantly suppressed the elevation of blood triglyceride after oral administration of a corn oil emulsion (8 mL oil/kg b.w.) to male ddY mice. Moreover, the antiobesity effects of BTE and GA were also evaluated in a mouse model of diet-induced obesity. Female ddY mice were divided into seven groups; normal diet (ND) group, high fat diet (HFD) group, BTE (0.2% and 0.6% of diets) groups, and GA (0.007%, 0.02% and 0.1% of diets) groups; the experimental groups were fed the test diets for 12 weeks. The BTE 0.6% and GA 0.1% groups showed significant suppression of weight gain. The weight of parametrial adipose tissue was strongly correlated with the body weight. These results suggest that GA contributes to the antiobesity effect of BTE as an active constituent by inhibiting pancreatic lipase activity. Copyright © 2011 John Wiley & Sons, Ltd.
Yasuyuki Oi; I-Ching Hou; Hiroyuki Fujita; Kazunaga Yazawa
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Publication Detail:
Type:  Journal Article     Date:  2011-08-16
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  26     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Research and Development Department, Nippon Supplement, Inc., 19-19, Chayamachi, Kita-Ku, Osaka, 530-0013, Japan.
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