Document Detail

Antinuclear antibody-negative systemic lupus erythematosus in a case with pregnancy.
MedLine Citation:
PMID:  20386913     Owner:  NLM     Status:  In-Data-Review    
We described a 30-year-old pregnant woman developing antinuclear antibodies (ANA)-negative systemic lupus erythematosus (SLE) accompanied with arthritis, malar rash, lymphopenia, autoimmune hemolytic anemia, pericardial and pleural effusion, proteinuria and seizures. All serum autoantibodies except anti-Ro antibody were negative. An artificially induced abortion was performed to prevent SLE deterioration. Steroid and cyclophosphamide therapy were effective for this patient. During the 2-year follow-up period, her ANA and other SLE-related autoantibodies in serum remained negative. This case suggests that ANA may not be required in the pathogenesis of SLE, even in the case with pregnancy, and ANA-negative SLE may also have a dangerous clinical course.
Qibing Xie; Yi Liu; Nanping Yang; Geng Yin
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Publication Detail:
Type:  Journal Article     Date:  2010-04-13
Journal Detail:
Title:  Rheumatology international     Volume:  32     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3273-6     Citation Subset:  IM    
Department of Rheumatology and Immunology, West China Hospital of Sichuan University, 610041, Chengdu, Sichuan, China.
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