Document Detail

Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol.
MedLine Citation:
PMID:  1475295     Owner:  NLM     Status:  MEDLINE    
A combination of tiletamine HCl and zolazepam HCl is frequently used as an anesthetic, but little is known about the antinociceptive properties of tiletamine-zolazepam. The antinociceptive properties of tiletamine-zolazepam alone or combined with xylazine or butorphanol were determined in the adult male rate using the tail-flick test. Changes in tail-flick latency were determined at 15, 45, and 75 min after IP drug administration of sterile water, sodium pentobarbital, morphine, tiletamine-zolazepam, xylazine, butorphanol, and tiletamine-zolazepam plus xylazine or butorphanol. Tail-flick latency approximated 100% maximum possible effect (MPE) at 15-75 min postinjection in morphine-treated rats. Tiletamine-zolazepam, xylazine, and butorphanol alone, at any dose utilized, produced less than 50% MPE. However, the combination of tiletamine-zolazepam with butorphanol or xylazine increased tail-flick latency approximately three times greater than tiletamine-zolazepam alone. These results demonstrate that: a) consonant with earlier findings, analgesia and anesthesia are independent states; b) tiletamine-zolazepam is not an effective combination with respect to analgesia; but c) in concert with appropriate drugs, it can exhibit potent antinociceptive properties.
R P Wilson; I S Zagon; D R Larach; C M Lang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  43     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-01     Completed Date:  1993-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1129-33     Citation Subset:  IM    
Department of Comparative Medicine, College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
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MeSH Terms
Analgesics / pharmacology*
Butorphanol / pharmacology*
Dose-Response Relationship, Drug
Drug Synergism
Nociceptors / drug effects
Rats, Sprague-Dawley
Reflex / drug effects
Sleep / drug effects
Tiletamine / pharmacology*
Xylazine / pharmacology*
Zolazepam / pharmacology*
Grant Support
Reg. No./Substance:
0/Analgesics; 14176-49-9/Tiletamine; 31352-82-6/Zolazepam; 42408-82-2/Butorphanol; 7361-61-7/Xylazine

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