Document Detail

Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis).
MedLine Citation:
PMID:  21627517     Owner:  NLM     Status:  In-Data-Review    
Objective-To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis). Animals-14 healthy adult Hispaniolan Amazon parrots of unknown sex. Procedures-3 doses of nalbuphine (12.5, 25, and 50 mg/kg, IM) and saline (0.9% NaCl) solution (control treatment) were evaluated in a blinded complete crossover experimental design by use of foot withdrawal threshold to a noxious thermal stimulus. Baseline data on thermal threshold were generated 1 hour before administration of nalbuphine or saline solution; thermal threshold measurements were obtained 0.5, 1.5, 3, and 6 hours after administration. Results-Nalbuphine administered IM at 12.5 mg/kg significantly increased the thermal threshold (mean change, 2.4°C), compared with results for the control treatment, and significantly changed thermal threshold for up to 3 hours, compared with baseline results (mean change, 2.6° to 3.8°C). Higher doses of nalbuphine did not significantly change thermal thresholds, compared with results for the control treatment, but had a significant effect, compared with baseline results, for up to 3 and 1.5 hours after administration, respectively. Conclusions and Clinical Relevance-Nalbuphine administered IM at 12.5 mg/kg significantly increased the foot withdrawal threshold to a thermal noxious stimulus in Hispaniolan Amazon parrots. Higher doses of nalbuphine did not result in significantly increased thermal thresholds or a longer duration of action and would be expected to result in less analgesic effect than lower doses. Further studies are needed to fully evaluate the analgesic effects of nalbuphine in psittacine species.
David Sanchez-Migallon Guzman; Butch Kukanich; Nicholas S Keuler; Julia M Klauer; Joanne R Paul-Murphy
Related Documents :
22225277 - Evaluation of the accuracy of 3dvh software estimates of dose to virtual ion chamber an...
3241337 - Chronotropic and inotropic effects of a new angiotensin converting enzyme inhibitor, mc...
9556237 - Mechanical, histologic, and biochemical effects of canine rectal formalin instillation.
18471147 - Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokinetics.
11930277 - Resistance to rocuronium in a child with schwartz-jampel syndrome type 1 b.
19941597 - Behavioural and insecticidal effects of organophosphate-, carbamate- and pyrethroid-tre...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  72     ISSN:  1943-5681     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  736-40     Citation Subset:  IM    
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sole depth and weight-bearing characteristics of the palmar surface of the feet of feral horses and ...
Next Document:  Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to H...