| Antinociceptive effects of combination of Tramadol and Acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats. | |
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MedLine Citation:
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PMID: 21453898 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to establish the streptozotocin (STZ)-induced diabetic model with rats and investigate the antinociceptive effect of combination of Tramadol (TR) and Acetaminophen (NAPA) on the animal model for the first time. METHODS: Diabetic model was induced by a single injection of STZ (60 mg/kg, intraperitoneal). Nociceptive thresholds were measured by means of electronic von Frey test, hot-plate test, and tail-flick test. On the 28th day of diabetes induction, diabetic rats with significant hyperalgesia were randomly divided into three groups: TR, NAPA, and TR-NAPA combination group. Each group was randomly divided into four subgroups. Three geometric series of drugs were given to each group respectively. Antinociceptive effects of the drugs were assessed at 15, 30, 60, 120, and 180 minutes after drug administration. 50% Maximum antinociceptive effect of each drug was determined by probit analysis, whereas interaction between TR and NAPA was evaluated by isobolographic analysis. RESULTS: Hyperalgesia, along with hyperglycemia, developed 4 days after STZ injection and persisted at all tested time points until 28 days. TR, NAPA, and TR-NAPA combination administration all produced dose-dependent antinociceptive effects. Isobolographic analysis showed a significant deviation of TR/NAPA 50% maximum antinociceptive effect (in tail-flick test, but not in von Frey test) from the additive line. CONCLUSIONS: Combination of the two drugs produces an additive antinociceptive effect in tail-flick test, whereas probable additive antinociceptive effect in von Frey test in painful diabetic neuropathy rats. |
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Authors:
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Ya-Hong Gong; Xue-Rong Yu; Hui-Li Liu; Nan Yang; Ping-Ping Zuo; Yu-Guang Huang |
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Publication Detail:
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Type: Journal Article Date: 2011-03-17 |
Journal Detail:
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Title: Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Volume: 49 ISSN: 1875-452X ISO Abbreviation: Acta Anaesthesiol Taiwan Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101214918 Medline TA: Acta Anaesthesiol Taiwan Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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