| Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice. | |
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MedLine Citation:
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PMID: 17049512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of methyleugenol, an essential oil isolated from Asiasari radix, on antinociception were examined using the formalin test in mice. Oral administration of 10 mg/kg methyleugenol significantly decreased the duration of licking and biting behavior in the second phase without affecting that of the first phase, as did diclofenac, a non-steroidal anti-inflammatory drug. Methyleugenol also inhibited pain-related behaviors induced by intrathecal injection of N-methyl-d-aspartic acid (NMDA), while diclofenac did not affect these behaviors. These effects of methyleugenol were suppressed by bicuculline, a gamma-aminobutyric acid(A) (GABA(A)) antagonist. Muscimol, a GABA(A) agonist, displays the same action as methyleugenol with respect to the formalin test and NMDA-induced behaviors. Methyleugenol did not affect cyclooxygenase-1 and -2 activities. These results suggest that the antinociceptive effect of methyleugenol on the second phase of formalin-induced pain may be due to the inhibition of NMDA receptor-mediated hyperalgesia via GABA(A) receptors. |
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Authors:
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Shingo Yano; Yasuyuki Suzuki; Mitsutoshi Yuzurihara; Yoshio Kase; Shuichi Takeda; Satoshi Watanabe; Masaki Aburada; Ken-Ichi Miyamoto |
Publication Detail:
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Type: Journal Article Date: 2006-09-23 |
Journal Detail:
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Title: European journal of pharmacology Volume: 553 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 99-103 Citation Subset: IM |
Affiliation:
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Central Research Laboratory, Research and Development Division, Tsumura and Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics
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therapeutic use* Animals Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Behavior, Animal / drug effects Cyclooxygenase 1 / metabolism Cyclooxygenase 2 / metabolism Diclofenac / therapeutic use Eugenol / analogs & derivatives*, therapeutic use Excitatory Amino Acid Agonists / pharmacology Formaldehyde* GABA Agonists / pharmacology Hyperalgesia / chemically induced*, drug therapy* Male Mice Muscimol / pharmacology N-Methylaspartate / pharmacology Nociceptors / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Excitatory Amino Acid Agonists; 0/GABA Agonists; 15307-86-5/Diclofenac; 2763-96-4/Muscimol; 50-00-0/Formaldehyde; 6384-92-5/N-Methylaspartate; 93-15-2/methyleugenol; 97-53-0/Eugenol; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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