Document Detail


Antinociceptive effect from Ipomoea cairica extract.
MedLine Citation:
PMID:  16307856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ipomoea cairica L. Sweet (Convolvulaceae) is used in Brazilian folk medicine for the treatment of rheumatism and inflammations. Ipomoea cairica ethanolic extract (100, 300, 1000 and 3000 mg/kg; per os) induced dose-dependent reduction of response in the formalin test inflammatory phase in mice. The same dose range did not modify neurogenic pain in formalin test, tail-flick reflex latency, carrageenan-induced paw edema, and Rota-Rod test motor performance. From the bio-active fraction 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid were obtained. These compounds have been previously reported to have analgesic and antioxidative effects. A possible explanation for the antinociception is that somehow the compounds present in the extract reduced the release of pro-nociceptive mediators unrelated to carrageenan-induced edema, such as histamine. Interestingly, caffeoylquinic acid derivatives have been reported to inhibit histamine release on in vitro models. The isolated caffeoylquinic acids could explain, at least in part, the antinociceptive effect of Ipomoea cairica polar extract.
Authors:
A A Ferreira; F A Amaral; I D G Duarte; P M Oliveira; R B Alves; D Silveira; A O Azevedo; D S Raslan; M S A Castro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-22
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  105     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-29     Completed Date:  2006-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Affiliation:
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Ipomoea / chemistry*
Magnetic Resonance Spectroscopy
Male
Mice
Plant Extracts / pharmacology*
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
0/Analgesics; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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