| Antinociceptive effect of crude extract, fractions and three alkaloids obtained from fruits of Piper tuberculatum. | |
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MedLine Citation:
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PMID: 19801849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the possible antinociceptive effect of the crude extract, fractions and pure compounds (three alkaloids) obtained from fruits of Piper tuberculatum JACQ. (Piperaceae) in acetic acid-induced visceral pain in mice. Oral administration of crude extract and fractions (CH(2)Cl(2), EtOAc, methanol and hexane) (3-300 mg kg(-1)) caused a dose-related and significant inhibition of the acetic acid-induced visceral nociceptive response. The crude extract, dichloromethane (CH(2)Cl(2)) and ethyl acetate (EtOAc) fractions were more potent than methanol and hexane fractions. The isolated alkaloids dihydro-piplartine, piplartine and 3,4,5-trimethoxydihydrocinnamic acid (0.0001-30 mg kg(-1)) exhibited significant and dose-related antinociceptive effects against acetic acid-induced visceral pain. The results show, for the first time, that crude extract, fractions and pure compounds obtained from P. tuberculatum produce marked antinociception against the acetic acid-induced visceral nociceptive response, supporting the ethnomedical use of P. tuberculatum. |
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Authors:
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Rosely Val??ria Rodrigues; D??bora Lanznaster; Daniela Tagliari Longhi Balbinot; Vin??cius de Maria Gadotti; Valdir Alves Facundo; Adair Roberto Soares Santos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 32 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1809-12 Citation Subset: IM |
Affiliation:
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Department of Medicine, Federal University of Rond??nia, Porto Velho, 78900-500, RO, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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chemically induced,
drug therapy* Acetic Acid Alkaloids / isolation & purification, pharmacology, therapeutic use* Analgesics / isolation & purification, pharmacology, therapeutic use* Animals Dose-Response Relationship, Drug Female Fruit Male Mice Phytotherapy* Piper / chemistry* Plant Extracts / chemistry, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Analgesics; 0/Plant Extracts; 64-19-7/Acetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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