Document Detail

Antinociceptive effect of crude extract, fractions and three alkaloids obtained from fruits of Piper tuberculatum.
MedLine Citation:
PMID:  19801849     Owner:  NLM     Status:  MEDLINE    
This study investigated the possible antinociceptive effect of the crude extract, fractions and pure compounds (three alkaloids) obtained from fruits of Piper tuberculatum JACQ. (Piperaceae) in acetic acid-induced visceral pain in mice. Oral administration of crude extract and fractions (CH(2)Cl(2), EtOAc, methanol and hexane) (3-300 mg kg(-1)) caused a dose-related and significant inhibition of the acetic acid-induced visceral nociceptive response. The crude extract, dichloromethane (CH(2)Cl(2)) and ethyl acetate (EtOAc) fractions were more potent than methanol and hexane fractions. The isolated alkaloids dihydro-piplartine, piplartine and 3,4,5-trimethoxydihydrocinnamic acid (0.0001-30 mg kg(-1)) exhibited significant and dose-related antinociceptive effects against acetic acid-induced visceral pain. The results show, for the first time, that crude extract, fractions and pure compounds obtained from P. tuberculatum produce marked antinociception against the acetic acid-induced visceral nociceptive response, supporting the ethnomedical use of P. tuberculatum.
Rosely Val??ria Rodrigues; D??bora Lanznaster; Daniela Tagliari Longhi Balbinot; Vin??cius de Maria Gadotti; Valdir Alves Facundo; Adair Roberto Soares Santos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  32     ISSN:  1347-5215     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1809-12     Citation Subset:  IM    
Department of Medicine, Federal University of Rond??nia, Porto Velho, 78900-500, RO, Brazil.
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MeSH Terms
Abdominal Pain / chemically induced,  drug therapy*
Acetic Acid
Alkaloids / isolation & purification,  pharmacology,  therapeutic use*
Analgesics / isolation & purification,  pharmacology,  therapeutic use*
Dose-Response Relationship, Drug
Piper / chemistry*
Plant Extracts / chemistry,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Alkaloids; 0/Analgesics; 0/Plant Extracts; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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