Document Detail

Antinociceptive effect of L-arginine in diabetic mice.
MedLine Citation:
PMID:  8206107     Owner:  NLM     Status:  MEDLINE    
The antinociceptive effect of L-arginine in streptozotocin-induced diabetic mice was examined. Although s.c. administration of L-arginine produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of L-arginine in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective delta-opioid receptor antagonist. However, neither beta-funaltrexamine, a selective mu-opioid receptor antagonist, nor nor-binaltorphimin ++, a selective kappa-opioid receptor antagonist, significantly affected the antinociceptive effect of L-arginine in diabetic and non-diabetic mice. These results suggest that L-arginine produces a marked antinociceptive effect in diabetic mice through the activation of delta-opioid receptors.
J Kamei; Y Iwamoto; M Misawa; H Nagase; Y Kasuya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  254     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-13     Completed Date:  1994-07-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
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MeSH Terms
Analgesics / administration & dosage,  antagonists & inhibitors,  pharmacology*
Arginine / administration & dosage,  analogs & derivatives,  antagonists & inhibitors,  pharmacology*
Diabetes Mellitus, Experimental / physiopathology*
Dose-Response Relationship, Drug
Endorphins / administration & dosage,  pharmacology
Injections, Intraventricular
Injections, Subcutaneous
Mice, Inbred ICR
Naltrexone / analogs & derivatives,  pharmacology
Narcotic Antagonists / pharmacology
Pain Measurement / drug effects
Reaction Time / drug effects
Reg. No./Substance:
0/Analgesics; 0/Endorphins; 0/Narcotic Antagonists; 105618-26-6/norbinaltorphimine; 111555-53-4/naltrindole; 16590-41-3/Naltrexone; 2149-70-4/Nitroarginine; 70904-56-2/kyotorphin; 72782-05-9/beta-funaltrexamine; 74-79-3/Arginine

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