| Antinociceptive effect of L-arginine in diabetic mice. | |
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MedLine Citation:
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PMID: 8206107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antinociceptive effect of L-arginine in streptozotocin-induced diabetic mice was examined. Although s.c. administration of L-arginine produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of L-arginine in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective delta-opioid receptor antagonist. However, neither beta-funaltrexamine, a selective mu-opioid receptor antagonist, nor nor-binaltorphimin ++, a selective kappa-opioid receptor antagonist, significantly affected the antinociceptive effect of L-arginine in diabetic and non-diabetic mice. These results suggest that L-arginine produces a marked antinociceptive effect in diabetic mice through the activation of delta-opioid receptors. |
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Authors:
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J Kamei; Y Iwamoto; M Misawa; H Nagase; Y Kasuya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 254 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-07-13 Completed Date: 1994-07-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 113-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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administration & dosage,
antagonists & inhibitors,
pharmacology* Animals Arginine / administration & dosage, analogs & derivatives, antagonists & inhibitors, pharmacology* Diabetes Mellitus, Experimental / physiopathology* Dose-Response Relationship, Drug Endorphins / administration & dosage, pharmacology Injections, Intraventricular Injections, Subcutaneous Male Mice Mice, Inbred ICR Naltrexone / analogs & derivatives, pharmacology Narcotic Antagonists / pharmacology Nitroarginine Pain Measurement / drug effects Reaction Time / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Endorphins; 0/Narcotic Antagonists; 105618-26-6/norbinaltorphimine; 111555-53-4/naltrindole; 16590-41-3/Naltrexone; 2149-70-4/Nitroarginine; 70904-56-2/kyotorphin; 72782-05-9/beta-funaltrexamine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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