Document Detail


Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis.
MedLine Citation:
PMID:  18270688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The agglutinin from the red marine alga Hypnea cervicornis (HCA) was tested in models of nociception and inflammation. The role of carbohydrate-binding sites and the systemic toxicity were assessed. HCA (10(-1), 1, and 10 mg/kg) administered i.v. to mice inhibited writhes induced by acetic acid and, at 10 mg/kg, inhibited the second phase of the formalin test, but did not alter the response latency in the hot-plate test. HCA (1 mg/kg) administered i.v. to rats reduced carrageenan-induced paw edema at 1, 2, and 3 h after challenge, but not edema induced by dextran. The neutrophil migration induced by both N-formyl-methionyl-leucyl-phenylalanine (fMLP) and carrageenan was inhibited by HCA at 10(-1), 1, and 10 mg/kg. The combination of HCA (1 mg/kg) and its ligand mucin reversed the lectin inhibitory effect on carrageenan-induced neutrophil migration and acetic acid-induced writhes. The i.v. treatment of rats with HCA (1 mg/kg) for 7 days did not affect body mass; liver, kidney or heart wet weight; blood leukocyte counts; urea, creatinine or serum transaminase activity; or macroscopy of the organs examined. In short, H. cervicornis agglutinin showed important antinociceptive and anti-inflammatory activity via interaction with the lectin carbohydrate-binding site.
Authors:
Flávio da S Bitencourt; Jozi G Figueiredo; Mário R L Mota; Carla C R Bezerra; Priscila P Silvestre; Marcus R Vale; Kyria S Nascimento; Alexandre H Sampaio; Celso S Nagano; Silvana Saker-Sampaio; Wladimir R L Farias; Benildo S Cavada; Ana M S Assreuy; Nylane M N de Alencar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-13
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  377     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-19     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  139-48     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Agglutinins / pharmacology*
Algae, Red / chemistry*
Analgesics / pharmacology*
Animals
Anti-Inflammatory Agents / pharmacology*
Lectins / pharmacology*,  toxicity
Male
Mice
Mucins / metabolism*
Pain Measurement
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Agglutinins; 0/Analgesics; 0/Anti-Inflammatory Agents; 0/Lectins; 0/Mucins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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