| Antinociceptive and anti-inflammatory effects of the monoterpene α,β-epoxy-carvone in mice. | |
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MedLine Citation:
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PMID: 23314829 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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α,β-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects. The present study investigated the antinociceptive and anti-inflammatory effects of EC. Intraperitoneal administration of EC at doses of 100, 200 or 300 mg/kg promoted a significant antinociceptive effect, as shown in the acetic acid-induced abdominal writhing test. EC also provoked a reduction in formalin-induced nociception in the first (300 mg/kg) and second phases (200 and 300 mg/kg). In the hot-plate test, an increase in response latency was found at 30 min (at 100, 200 and 300 mg/kg), and at 60 and 120 min (at 300 mg/kg) following administration of EC, an effect that was reversed by naloxone. Intraperitoneal administration of EC (300 mg/kg) inhibited the increased vascular permeability provoked by acetic acid. These findings suggest that EC inhibited the acute inflammatory reaction, with a pronounced peripheral and central antinociceptive effect in mice that is probably associated with activation of the opioidergic system, which appears to play a role in the antinociceptive activity induced by EC. |
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Authors:
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Marilene L da Rocha; Leandra E G Oliveira; Camila C M Patrício Santos; Damião P de Sousa; Reinaldo N de Almeida; Demetrius A M Araújo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: Journal of natural medicines Volume: - ISSN: 1861-0293 ISO Abbreviation: J Nat Med Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101518405 Medline TA: J Nat Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biological Sciences, State University of Feira de Santana (UEFS), Av. Transnordestina, S/N, Novo Horizonte, Feira de Santana, Bahia, 44036-900, Brazil, mlrochaph@gmail.com. |
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