Document Detail


Antinociceptive activity of the volatile oils of Hyptis pectinata L. Poit. (Lamiaceae) genotypes.
MedLine Citation:
PMID:  17950588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyptis pectinata L. Poit (Lamiaceae) is known popularly in Brazil as "sambacaita" or "canudinho" and is used in the treatment of inflammations, bacterial infections and ache. The antinociceptive activity of the volatile oils of six genotypes, at doses of 100, 200 and 400mg/kg body wt., were investigated using abdominal writhe models induced by acetic acid and hot plate tests. The volatile oils of all the genotypes are composed mainly of sesquiterpenoids. All the genotypes showed antinociceptive effects in both models used; the SAM002 genotype showed the major inhibitory effect at dose of 100mg/kg body wt. These results suggest that the volatile oil of H. pectinata has peripheral (writhe reduction) and central (time delay of thermal reaction) effects. These observations indicate that H. pectinata may be useful as an analgesic drug.
Authors:
M F Arrigoni-Blank; A R Antoniolli; L C Caetano; D A Campos; A F Blank; P B Alves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-22
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  15     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  334-9     Citation Subset:  IM    
Affiliation:
Núcleo de Ciências Biológicas, Campus Prof. Alberto Carvalho, Universidade Federal de Sergipe, Itabaiana, Av. Vereador Olímpio Grande s/n, 49500-000 Sergipe, Brazil. fatima.blank@terra.com.br
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MeSH Terms
Descriptor/Qualifier:
Analgesics / chemistry,  pharmacology,  therapeutic use*
Animals
Female
Genotype
Hyptis / chemistry*,  classification,  genetics
Male
Mice
Oils, Volatile / chemistry,  pharmacology,  therapeutic use*
Pain / drug therapy*
Phytotherapy*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Oils, Volatile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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