Document Detail

Antinociceptive activity of ricinoleic acid, a capsaicin-like compound devoid of pungent properties.
MedLine Citation:
PMID:  11050297     Owner:  NLM     Status:  MEDLINE    
The antinociceptive effect of ricinoleic acid ([R-(Z)]-12-hydroxy-9-octadecenoic acid) in comparison with capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) has been investigated in several "in vivo" tests. Acute topical application of capsaicin, but not ricinoleic acid, produced by itself an hyperalgesic effect detected as a decrease in paw withdrawal latency in response to a painful (heat) stimulus in mice. Capsaicin, but not ricinoleic acid at any dose tested, showed an irritant effect in the wiping test in guinea pig conjunctiva after local application and in the paw licking test in mice after intradermal injection. Whereas acute application of ricinoleic acid or capsaicin decreased paw withdrawal latency to heat in the presence of a pre-existing inflammation (injection of carrageenan in the mouse paw), the repeated local treatment for 8 days with either compounds markedly increased paw withdrawal latency. In a chronic model of inflammation (complete Freund's adjuvant arthritis in mice), the repeated topical and intradermal treatments with both ricinoleic acid and capsaicin increased paw withdrawal latency to heat, the antinociceptive effect of ricinoleic acid being more persistent than that of capsaicin. Antinociceptive effect of 8 days of treatment with ricinoleic acid and capsaicin was observed in acetic acid-induced writhing in mice, capsaicin-induced foot licking in mice and capsaicin-induced wiping movements in guinea pig conjunctiva. A decrease of substance P tissue levels in the mouse paw was found after repeated treatment with ricinoleic acid. In conclusion, ricinoleic acid seems to be a new antinociceptive agent lacking the pungent and acute hyperalgesic properties of capsaicin.
C Vieira; S Evangelista; R Cirillo; R Terracciano; A Lippi; C A Maggi; S Manzini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  407     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-29     Completed Date:  2000-12-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Department of Pharmacology, Menarini Ricerche SpA, Roma, Pomezia, Italy.
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MeSH Terms
Administration, Topical
Capsaicin / pharmacology*,  therapeutic use
Conjunctiva / drug effects*,  physiology
Guinea Pigs
Hindlimb / drug effects,  physiology
Hot Temperature
Hyperalgesia / drug therapy
Inflammation / chemically induced,  drug therapy
Pain Measurement / drug effects*
Ricinoleic Acids / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Ricinoleic Acids; 141-22-0/ricinoleic acid; 404-86-4/Capsaicin; 9000-07-1/Carrageenan

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