| Antinociceptive action of hemopressin in experimental hyperalgesia. | |
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MedLine Citation:
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PMID: 15652650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied. In this work, we examined the influence of hemopressin on inflammatory pain. Hemopressin reverted the hyperalgesia induced by either carrageenin or bradykinin when injected concomitantly or 2.5 h after the phlogistic agents. Hemopressin administered systemically also reverted the hyperalgesia induced by carrageenin. Naloxone did not prevent the antinociceptive action of this peptide. These data suggest that hemopressin inhibits peripheral hyperalgesic responses by mechanisms independent of opioid receptor activation. |
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Authors:
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Camila Squarzoni Dale; Rosana de Lima Pagano; Vanessa Rioli; Stephen Hyslop; Renata Giorgi; Emer Suavinho Ferro |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peptides Volume: 26 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: IM |
Affiliation:
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Laboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology Animals Blood Pressure Bradykinin / pharmacology Carrageenan / pharmacology Disease Models, Animal Endorphins Hemoglobins / chemistry, pharmacology* Hyperalgesia / chemically induced, drug therapy* Inflammation Male Naloxone / pharmacology Narcotic Antagonists / pharmacology Pain Pain Measurement Peptide Fragments / pharmacology* Peptides / chemistry, therapeutic use Rats Rats, Wistar Receptors, Opioid / chemistry Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Endorphins; 0/Hemoglobins; 0/Narcotic Antagonists; 0/Peptide Fragments; 0/Peptides; 0/Receptors, Opioid; 0/hemopressin; 465-65-6/Naloxone; 58-82-2/Bradykinin; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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