Document Detail

Antinociceptive action of hemopressin in experimental hyperalgesia.
MedLine Citation:
PMID:  15652650     Owner:  NLM     Status:  MEDLINE    
Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied. In this work, we examined the influence of hemopressin on inflammatory pain. Hemopressin reverted the hyperalgesia induced by either carrageenin or bradykinin when injected concomitantly or 2.5 h after the phlogistic agents. Hemopressin administered systemically also reverted the hyperalgesia induced by carrageenin. Naloxone did not prevent the antinociceptive action of this peptide. These data suggest that hemopressin inhibits peripheral hyperalgesic responses by mechanisms independent of opioid receptor activation.
Camila Squarzoni Dale; Rosana de Lima Pagano; Vanessa Rioli; Stephen Hyslop; Renata Giorgi; Emer Suavinho Ferro
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  26     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-01-17     Completed Date:  2005-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Laboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil.
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MeSH Terms
Analgesics / pharmacology
Blood Pressure
Bradykinin / pharmacology
Carrageenan / pharmacology
Disease Models, Animal
Hemoglobins / chemistry,  pharmacology*
Hyperalgesia / chemically induced,  drug therapy*
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Pain Measurement
Peptide Fragments / pharmacology*
Peptides / chemistry,  therapeutic use
Rats, Wistar
Receptors, Opioid / chemistry
Time Factors
Reg. No./Substance:
0/Analgesics; 0/Endorphins; 0/Hemoglobins; 0/Narcotic Antagonists; 0/Peptide Fragments; 0/Peptides; 0/Receptors, Opioid; 0/hemopressin; 465-65-6/Naloxone; 58-82-2/Bradykinin; 9000-07-1/Carrageenan

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