| Antinociception and anti-inflammation induced by simvastatin in algesiometric assays in mice. | |
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MedLine Citation:
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PMID: 21699658 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Statins, belonging to a well-known drug class used for lowering cholesterol through competitive inhibition of HMG-CoA (3-hydroxy-3methyl-glutaryl-coenzyme A) reductase, also have other pleiotropic properties, such as anti-inflammatory action. The purpose of this study was to evaluate the antinociceptive and anti-inflammatory effects of simvastatin in five models of nociceptive behaviour. Oral gavage administration of simvastatin induced a dose-dependent inhibition of nociception for 1 day in the acetic acid writhing (ED(50) = 5.59 ± 0.07), tail flick (ED(50) = 112.96 ± 8.00), hot plate (ED(50) = 134.87 ± 2.20), formalin hind paw (ED(50) = 19.86 ± 1.12, in phase I and 23.30 ± 2.05, in phase II) and orofacial formalin (ED(50) = 5.54 ± 2.74, in phase I and 11.48 ± 1.88, in phase II) tests. However, after 3 days, the values were in the acetic acid writhing (ED(50) = 6.14 ± 0.51), tail flick (ED(50) = 154 ± 8.88), hot plate (ED(50) = 136.14 ± 2.94), formalin hind paw (ED(50) = 15.93 ± 0.42, in phase I and 17.10 ± 1.80, in phase II) and orofacial formalin (ED(50) = 6.79 ± 0.66, in phase I and 5.80 ± 1.49, in phase II) tests. This study demonstrated the antinociceptive and anti-inflammatory activities of simvastatin in five models of tonic or phasic pain. These actions seem to be related to the inhibition of cytokine and prostanoid release and stimulation of nitric oxide synthesis. A possible clinical role of simvastatin could be related to the potentially beneficial effects in the neuropathic pain and by their pleiotropic properties, they could play a clinical role in anti-inflammatory disease. |
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Authors:
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Hugo F Miranda; Viviana Noriega; Loreto Olavarria; Ramiro J Zepeda; Fernando Sierralta; Juan C Prieto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-23 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: - ISSN: 1742-7843 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Basic & Clinical Pharmacology & Toxicology © 2011 Nordic Pharmacological Society. |
Affiliation:
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Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile Faculty of Medicine, School of Pharmacy, University of Andrés Bello, Santiago, Chile Cardiovascular Department, Clinical Hospital, University of Chile, Santiago, Chile. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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