Document Detail


Antineuronal antibodies in patients with neuroblastoma: relationships with clinical features.
MedLine Citation:
PMID:  9526591     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the frequency of serum antineuronal antibodies in a cohort of 39 neuroblastoma patients and related their presence to clinical features. Twelve patients displayed antineuronal antibodies at immunocytochemistry. Only one of these 12 patients suffered from a clinically overt paraneoplastic syndrome. No significant differences emerged between autoantibody-positive and autoantibody-negative patients in terms of progression-free and overall survival, although when only patients evolving to disease progression were considered, the time interval between diagnosis and progression was slightly longer in autoantibody-positive patients.
Authors:
A Salmaggi; R Luksch; M G Forno; A Pozzi; A Silvani; A Boiardi; M Gasparini; R Nemni
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tumori     Volume:  83     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  953-7     Citation Subset:  IM    
Affiliation:
Istituto Nazionale Neurologico C. Besta, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Autoantibodies / blood*
Blotting, Western
Child
Child, Preschool
Cohort Studies
Disease Progression
Female
Humans
Immunohistochemistry
Infant
Male
Neuroblastoma / immunology*,  mortality,  pathology
Neurons / immunology*
Paraneoplastic Syndromes
Survival Analysis
Chemical
Reg. No./Substance:
0/Autoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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