Document Detail

Antineuronal (anti-Ri) antibodies in a patient with steroid-responsive opsoclonus-myoclonus.
MedLine Citation:
PMID:  8423887     Owner:  NLM     Status:  MEDLINE    
A 45-year-old woman developed opsoclonus, myoclonus, and severe truncal and gait ataxia. Serum and CSF contained IgG antibodies that appear to be identical to "anti-Ri" antibodies associated with paraneoplastic opsoclonus and ataxia. The patient had a fluctuating course with exacerbations that responded well to corticosteroids and later to cyclophosphamide. Her anti-Ri antibody titer has declined significantly but still remains high. After more than 3 years of follow-up, no neoplasm has been detected.
E J Dropcho; L B Kline; J Riser
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-23     Completed Date:  1993-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  AIM; IM    
Department of Neurology, University of Alabama, Birmingham.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Antibodies, Anti-Idiotypic / analysis*
Cyclophosphamide / therapeutic use
Diplopia / etiology
Immunoglobulin G / immunology*
Middle Aged
Myoclonus / drug therapy*,  immunology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin G; 50-18-0/Cyclophosphamide

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