Document Detail

Antineuronal antibodies in migraine patients with white matter lesions.
MedLine Citation:
PMID:  20942595     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT Magnetic resonance imaging (MRI) studies occasionally display focal hyperintense lesions within the white matter of migraine patients. No immunological factors associated with these lesions have been defined so far. To investigate the relationship between MRI lesions and antineuronal antibody response, 17 migraine patients with white matter lesions (WML), 19 migraine patients without WML, 20 multiple sclerosis patients with WML and with no headache history, and 20 healthy individuals were enrolled, and their sera were examined by indirect immunohistochemistry for the presence of immunoglobulin G (IgG) reacting with the rat brain tissue. Migraine patients with and without WML essentially showed identical demographic and clinical features and frequencies of systemic autoantibodies. However, migraine patients with WML displayed a significantly higher frequency of antineuronal antibodies than those without WML (12/17 vs. 2/19, p = .0004). Serum IgG of migraine patients predominantly reacted with the cytoplasm of neurons and the molecular layer of cerebellum. None of the multiple sclerosis patients and healthy controls displayed antineuronal antibodies. Our results imply the involvement of inflammation in migraine pathogenesis.
Recai Türkoğlu; Erdem Tüzün; Sema Içöz; Omer Birişik; Ece Erdağ; Murat Kürtüncü; Gulsen Akman-Demir
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Publication Detail:
Type:  Journal Article     Date:  2010-10-13
Journal Detail:
Title:  The International journal of neuroscience     Volume:  121     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
1Department of Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
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