| Antineoplastic activity and toxicity of an organometallic complex of ruthenium(II) in comparison with cis-PDD in mice bearing solid malignant neoplasms. | |
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MedLine Citation:
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PMID: 6540184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antineoplastic activity of an organometallic complex of ruthenium(II), [cis-RuCl2(DMSO)4]o, has been examined in comparison with that of cis-PDD, using three metastasizing tumors of the mouse: Lewis lung carcinoma, B16 melanoma and MCa mammary carcinoma. [cis-RuCl2(DMSO)4]o significantly reduces primary tumor growth in all the tumors tested, and its activity is similarly pronounced at three different dosages in mice bearing Lewis lung carcinoma. On the contrary, the survival time of animals having i.v. or i.m. tumor implants are only moderately increased, and also in the case of combined treatments with surgery. The antineoplastic activity of cis-PDD appears to be less pronounced than that of [cis-RuCl2(DMSO)4]o, and is limited to mice bearing B16 melanoma, which, among the three tumors used, appears to be naturally more responsive to cis-PDD and [cis-RuCl2(DMSO)4]o. The use of [cis-RuCl2(DMSO)4]o appears advantageous over that of cis-PDD since, unlike cis-PDD, its antineoplastic effects have been obtained at dosages with reduced host toxicity, indicated by the absence of significant hematological toxicity and toxicity for normal proliferating tissues. |
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Authors:
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G Sava; S Zorzet; T Giraldi; G Mestroni; G Zassinovich |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cancer & clinical oncology Volume: 20 ISSN: 0277-5379 ISO Abbreviation: Eur J Cancer Clin Oncol Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-08-27 Completed Date: 1984-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112045 Medline TA: Eur J Cancer Clin Oncol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 841-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use*, toxicity Blood Cell Count Cell Survival / drug effects Cisplatin / therapeutic use*, toxicity Dose-Response Relationship, Drug Female Lung Neoplasms / drug therapy, secondary Mammary Neoplasms, Experimental / drug therapy Melanoma / drug therapy Mice Mice, Inbred Strains Neoplasm Transplantation Neoplasms, Experimental / drug therapy* Organometallic Compounds / therapeutic use*, toxicity Ruthenium / therapeutic use*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Organometallic Compounds; 11070-19-2/dichlorotetrakis(dimethyl sulfoxide)ruthenium II; 15663-27-1/Cisplatin; 7440-18-8/Ruthenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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