Document Detail


Antineophobic effect of the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one in male rats.
MedLine Citation:
PMID:  9610934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one (pregnanolone) and benzodiazepine receptor (BZR) agonists share sedative, anxiolytic, and anticonvulsant properties. Recent evidence suggests that like BZR agonists, pregnanolone may also modulate feeding responses. The present experiments examined the behavioral mechanisms responsible for any hyperphagic effect of pregnanolone. The effect of pregnanolone (1-10 mg/kg i.p.) on the intake and microstructure of licking for two sucrose solutions (1 and 3%) in well familiarized nondeprived male rats under either light or dark conditions was examined. Pregnanolone had no effect on either intake or the duration or number of bouts of licking in these experiments, although in all cases the intrabout lick rate was significantly reduced at the highest dose. Pregnanolone (1-10 mg/kg) also failed to increase intake of a sweet wet mash in familiarized nondeprived male rats. However, in a food choice test where both novel and familiar food items were available, pregnanolone (1-3 mg/kg) significantly increased the time spent eating the novel food. These results suggest that unlike BZR agonists, which enhance feeding responses directly, pregnanolone may facilitate feeding secondarily via an attenuation of anxiety.
Authors:
S Higgs; S J Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  60     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-27     Completed Date:  1998-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Durham, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects,  physiology
Circadian Rhythm
Dietary Sucrose / administration & dosage
Eating / drug effects,  physiology
Feeding Behavior / drug effects*,  physiology
Hyperphagia / chemically induced,  physiopathology,  psychology
Male
Pregnanolone / pharmacology*,  physiology
Rats
Receptors, GABA-A / agonists,  physiology
Chemical
Reg. No./Substance:
0/Dietary Sucrose; 0/Receptors, GABA-A; 128-20-1/Pregnanolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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