Document Detail

Antimycoplasmal activities of the pseudomonic acids and structure-activity relationships of monic acid A derivatives.
MedLine Citation:
PMID:  3133344     Owner:  NLM     Status:  MEDLINE    
The antimycoplasmal activities of the pseudomonic acids isolated from Pseudomonas fluorescens NCIB 10586 are reported. Structure-activity relationships of a variety of ester, amide and thiol ester derivatives of the nucleus, monic acid A, are described. Enhanced antimycoplasmal activity is reported for a number of monic acid A esters and the most potent derivative, m-nitrobenzyl monate A, is a 100-fold more active against Mycoplasma hyopneumoniae than pseudomonic acid A.
R M Banks; A C Donald; P C Hannan; P J O'Hanlon; N H Rogers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  41     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-08-02     Completed Date:  1988-08-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  609-13     Citation Subset:  IM    
Beecham Pharmaceuticals Research Division, Tadworth, Surrey, UK.
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MeSH Terms
Anti-Bacterial Agents* / chemical synthesis
Chemistry, Pharmaceutical
Esters / pharmacology
Fatty Acids / pharmacology
Mycoplasma / drug effects
Pyrans / chemical synthesis,  pharmacology
Structure-Activity Relationship
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Esters; 0/Fatty Acids; 0/Pyrans; 12650-69-0/Mupirocin; 66262-68-8/monic acid A

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