| Antimycobacterial activity: synthesis of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues. | |
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MedLine Citation:
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PMID: 21714764 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this study, a series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis (MTB) H(37)Rv and isoniazid resistant M. tuberculosis (INHR-MTB). All the newly synthesized compounds were showing moderate to high inhibitory activities. The compound 6,7-dimethoxy-3-(4-chloro phenyl)-4H-indeno[1,2-c]isoxazole (4b) was found to be the most promising compound, active against MTB H(37)Rv and INHR-MTB with minimum inhibitory concentrations of 0.22 and 0.34 μM. |
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Authors:
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Mohamed Ashraf Ali; Rusli Ismail; Tan Soo Choon; Suresh Pandian; Mohamed Zaheen Hassan Ansari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of enzyme inhibition and medicinal chemistry Volume: 26 ISSN: 1475-6374 ISO Abbreviation: J Enzyme Inhib Med Chem Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150203 Medline TA: J Enzyme Inhib Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 598-602 Citation Subset: IM |
Affiliation:
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Pharmacogenetic and Novel Therapeutic, Institute for Research in Molecular Medicine, Universiti of Sains Malysia, Pennag-11800, Malaysia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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