Document Detail

Antimycobacterial activity of lichen substances.
MedLine Citation:
PMID:  19683421     Owner:  NLM     Status:  MEDLINE    
We describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity. The depsides (atranorin, diffractaic and lecanoric acids), depsidones (protocetraric, salazinic, hypostictic and norstictic acids), xanthones (lichexanthone and secalonic acid), and usnic acid, as well seven orsellinic acid esters, five salazinic acid 8',9'-O-alkyl derivatives and four lichexanthone derivatives, were evaluated for their activity against Mycobacterium tuberculosis. Diffractaic acid was the most active compound (MIC value 15.6mug/ml, 41.6 microM), followed by norstictic acid (MIC value 62.5 microg/ml, 168 microM) and usnic acid (MIC value 62.5 microg/ml, 182 microM). Hypostictic acid (MIC value 94.0 microg/ml, 251 microM) and protocetraric acid (MIC value 125 microg/ml, 334 microM) showed moderate inhibitory activity. The other compounds showed lower inhibitory activity on the growth of M. tuberculosis, varying from MIC values of 250 to 1370 microM.
N K Honda; F R Pavan; R G Coelho; S R de Andrade Leite; A C Micheletti; T I B Lopes; M Y Misutsu; A Beatriz; R L Brum; C Q F Leite
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-14
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  17     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  328-32     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier GmbH. All rights reserved.
Universidade Federal de Mato Grosso do Sul, Departamento de Química, 79070-900 Campo Grande, MS, Brazil.
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MeSH Terms
Antitubercular Agents / isolation & purification,  pharmacology*
Lichens / chemistry*
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Phenols / isolation & purification,  pharmacology*
Plant Extracts / chemistry,  pharmacology*
Usnea / chemistry*
Reg. No./Substance:
0/Antitubercular Agents; 0/Phenols; 0/Plant Extracts

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