Document Detail


Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.
MedLine Citation:
PMID:  19444772     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
Authors:
Michael Koch; Tim S Bugni; Chris D Pond; Mohammad Sondossi; Manah Dindi; Pius Piskaut; Chris M Ireland; Louis R Barrows
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-14
Journal Detail:
Title:  Planta medica     Volume:  75     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2010-02-16     Revised Date:  2010-04-29    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1326-30     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart, New York.
Affiliation:
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry,  isolation & purification,  pharmacology*
Chemical Fractionation
Diynes / chemistry,  isolation & purification,  pharmacology*
Fatty Acids, Unsaturated / chemistry,  isolation & purification,  pharmacology*
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Plant Extracts / chemistry,  isolation & purification,  pharmacology
Santalaceae / chemistry*
Grant Support
ID/Acronym/Agency:
5U01TW006671-05/TW/FIC NIH HHS; RR06262/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Diynes; 0/Fatty Acids, Unsaturated; 0/Plant Extracts; 0/exocarpic acid

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