| Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid. | |
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MedLine Citation:
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PMID: 19444772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra. |
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Authors:
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Michael Koch; Tim S Bugni; Chris D Pond; Mohammad Sondossi; Manah Dindi; Pius Piskaut; Chris M Ireland; Louis R Barrows |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-05-14 |
Journal Detail:
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Title: Planta medica Volume: 75 ISSN: 1439-0221 ISO Abbreviation: Planta Med. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-07 Completed Date: 2010-02-16 Revised Date: 2010-04-29 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 1326-30 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart, New York. |
Affiliation:
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Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry,
isolation & purification,
pharmacology* Chemical Fractionation Diynes / chemistry, isolation & purification, pharmacology* Fatty Acids, Unsaturated / chemistry, isolation & purification, pharmacology* Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects* Plant Extracts / chemistry, isolation & purification, pharmacology Santalaceae / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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5U01TW006671-05/TW/FIC NIH HHS; RR06262/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Diynes; 0/Fatty Acids, Unsaturated; 0/Plant Extracts; 0/exocarpic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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