Document Detail

Antimutagenicity of propionic acid bacteria.
MedLine Citation:
PMID:  1720873     Owner:  NLM     Status:  MEDLINE    
The antimutagenic effect of dialysed cell extracts of 4 strains of propionic acid bacteria was examined against the mutagenicity of sodium azide in the TA1535 tester strain of Salmonella typhimurium using the Ames test. It was noted that dialysates of 2 strains of Propionibacterium shermanii, P. pentosaceum and P. acnes, significantly reduced sodium azide-induced revertants. The dialysate of propionic acid cocci did not show an antimutagenic effect. The inhibitory activity was enhanced if the mutagen and extract were coincubated for 20 min prior to performing the mutagenicity assay. Antimutagenicity of dialysates from P. shermanii VKM-103 against MNNG and 9-aminoacridine was shown in S. typhimurium strains TA1535 and TA97. The antimutagenic activity was found in the protein fraction of the cell extract of P. shermanii. The proteins of the dialysate of P. shermanii were separated using a Toyopearl gel column into 3 main peaks according to their molecular weights. The antimutagenic activity towards sodium azide was found in the second and the third peaks. We suggest that dialysates of the cells of propionic acid bacteria contain several kinds of antimutagenic substances with different molecular weights.
L I Vorobjeva; T A Cherdinceva; S K Abilev; N V Vorobjeva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  251     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-14     Completed Date:  1992-01-14     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-9     Citation Subset:  IM    
Department of Microbiology, Biology Faculty, Moscow State University, U.S.S.R.
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MeSH Terms
Aminacrine / toxicity
Antimutagenic Agents / pharmacology*
Azides / antagonists & inhibitors*,  toxicity
Methylnitronitrosoguanidine / antagonists & inhibitors,  toxicity
Mutagenicity Tests
Propionibacterium / metabolism*
Propionic Acids / pharmacology*
Salmonella typhimurium / drug effects
Sodium Azide
Vitamin B 12 / analysis
Reg. No./Substance:
0/Antimutagenic Agents; 0/Azides; 0/Propionic Acids; 26628-22-8/Sodium Azide; 68-19-9/Vitamin B 12; 70-25-7/Methylnitronitrosoguanidine; 79-09-4/propionic acid; 90-45-9/Aminacrine

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