| Antimutagenic potential of the Thai herb, Mucuna collettii Lace. | |
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MedLine Citation:
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PMID: 17964098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mucuna collettii Lace is a Thai herb with a long record of consumption among mature Thai males for the promotion of sexual potency. The mutagenic and antimutagenic potentials of Mucuna collettii extract were carried out by using the Ames test pre-incubation method in the presence and absence of S9 mixture. Salmonella typhimurium strains TA 98 and TA 100 were applied as the tester strains. Prior to mutagenic and antimutagenic tests, the survival of the tester strains was performed by treating with the plant extract. Results showed Mucuna collettii extract exhibited strong cytotoxic effects in a dose-dependent manner. Toxicity of the plant was confirmed in mice in which negative adverse effect was found in kidney, uterus, ovary, and testis. Mucuna collettii extract in the presence and absence of S9 mixture was negative for mutagenic Ames test. Mucuna collettii extract in the presence and absence of S9 mixture was positive for antimutagenic Ames test towards either one or both of the tested mutagens: 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) and benzo(a)pyrene. The antimutagenic activity of the plant extract was confirmed in rec-assays. Micronucleus test demonstrated that Mucuna collettii extract at high dose and a long incubation time could induce micronucleus formation in tested animals, but less than the response of the positive control. The overall mutagenic and antimutagenic assays are further evidences for the antimutagenic potential of Mucuna collettii. |
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Authors:
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Wichai Cherdshewasart; Wandee Sutjit; Kade Pulcharoen; Rattana Panriansaen; Malyn Chulasiri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-18 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 115 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-04-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 96-103 Citation Subset: IM |
Affiliation:
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Department of Biology, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand. cwichai@sc.chula.ac.th |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimutagenic Agents / administration & dosage, pharmacology*, toxicity Benzo(a)pyrene / toxicity Dose-Response Relationship, Drug Female Furylfuramide / toxicity Male Medicine, East Asian Traditional Mice Mice, Inbred ICR Micronucleus Tests Mucuna / chemistry* Mutagenicity Tests Mutagens / administration & dosage, pharmacology*, toxicity Plant Extracts / pharmacology, toxicity Rats Rats, Wistar Salmonella typhimurium / drug effects, genetics Thailand Toxicity Tests, Chronic |
| Chemical | |
Reg. No./Substance:
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0/Antimutagenic Agents; 0/Mutagens; 0/Plant Extracts; 3688-53-7/Furylfuramide; 50-32-8/Benzo(a)pyrene |
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