Document Detail


Antimutagenic in vitro activity of plant polyphenols: Pycnogenol and Ginkgo biloba extract (EGb 761).
MedLine Citation:
PMID:  18167041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ofloxacin (15 microg/mL) and acridine orange (5 microg/mL) induce mutagenicity by different mechanisms in the photosynthetic flagellate Euglena gracilis. The present study examined whether Pycnogenol (PYC; 5-100 microg/mL) or Ginkgo biloba extract (EGb 761; 5-100 microg/mL) could protect against the mutagenic effects of each of the mutagens and the potential mechanisms underlying such protection. The highest concentration of PYC and EGb 761 effectively reduced the mutagenic activity of both ofloxacin and acridine orange by more than 99% (p < 0.001). Using luminol-dependent photochemical methodology it was demonstrated that EGb 761 and PYC were effective antioxidants. In addition, as determined by spectrophotometry, PYC and EGb 761 bound acridine orange. Both PYC and EGb 761 have been shown to produce dual antimutagenic effects, as evidenced by both antioxidant and physicochemical properties. The findings suggest that EGb 761 and PYC would thus be suitable for future study, not only as antioxidants, but also as antimutagenic agents.
Authors:
Lívia Krizková; Zuzana Chovanová; Zdenka Duracková; Juraj Krajcovic
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  22     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  384-8     Citation Subset:  IM    
Affiliation:
Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Mlynská dolina, 842 15 Bratislava, Slovak Republic. krizkova@fns.uniba.sk
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MeSH Terms
Descriptor/Qualifier:
Acridine Orange / metabolism,  pharmacology
Animals
Antimutagenic Agents / pharmacology*
Cattle
DNA / drug effects
Euglena gracilis / drug effects*
Flavonoids / metabolism,  pharmacology*
Models, Animal
Mutagens / pharmacology
Ofloxacin / pharmacology
Plant Extracts / metabolism,  pharmacology*
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
0/Antimutagenic Agents; 0/Flavonoids; 0/Ginkgo biloba extract 761; 0/Mutagens; 0/Plant Extracts; 0/pycnogenols; 65-61-2/Acridine Orange; 82419-36-1/Ofloxacin; 9007-49-2/DNA; 91080-16-9/calf thymus DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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