Document Detail


Antimutagenic effect of phenolic acids.
MedLine Citation:
PMID:  16601817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, the Salmonella typhimurium tester strain TA 100 was used in the plate-incorporation test to examine the antimutagenic potential of caffeic, ferulic and cichoric acids extracted from plant species of genera Echinacea (L) Moench, as well as of another phenolic acids, on 3-(5-nitro-2-furyl)acrylic acid (5NFAA) and sodium azide mutagenicity. All tested compounds possess antimutagenic activity. In the case of 5NFAA, the antimutagenic potency of tested compounds was in the order of gallic acid > ferulic acid > caffeic acid > syringic acid > vanillic acid. The mutagenic effect of sodium azide was inhibited by tested phenolic acids by about 20-35 %. The most effective compound, gallic acid inhibits this effect by 82 % in the concentration of 500 mug/plate. The only exception from favourable properties of tested phenolic acids is cichoric acid, which in the contrary significantly increased the mutagenic effect of 5NFAA.
Authors:
Lucia Birosová; Mária Mikulásová; Stefánia Vaverková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia     Volume:  149     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-04-07     Completed Date:  2007-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  489-91     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Microbiology, Faculty of Food and Chemical Technology, Slovak University of Technology, Bratislava, Slovakia. lucia.birosova@stuba.sk
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MeSH Terms
Descriptor/Qualifier:
Antimutagenic Agents / pharmacology*
Mutagenicity Tests
Mutagens / pharmacology
Mutation / drug effects*
Phenols / pharmacology*
Plant Extracts / pharmacology*
Salmonella typhimurium / drug effects,  genetics
Chemical
Reg. No./Substance:
0/Antimutagenic Agents; 0/Mutagens; 0/Phenols; 0/Plant Extracts

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