Document Detail

Antimutagenic effect of one variety of green pepper (Capsicum spp.) and its possible interference with the nitrosation process.
MedLine Citation:
PMID:  11551479     Owner:  NLM     Status:  MEDLINE    
It is known that the poblano green pepper, a significant component in the Mexican diet, contains certain natural compounds such as chlorophyll, beta-carotene, and vitamins, which have antimutagenic and/or anticarcinogenic properties. Using the somatic mutation and recombination test in wing cells of Drosophila melanogaster, an extract of the poblano pepper (Capsicum spp.) was evaluated to determine its antimutagenic effect against the nitrosation process, simulating the process occurring in the human stomach caused by known food additives. Larvae of 72h old D. melanogaster of standard (ST) and high bioactivation (HB) crosses were exposed in a simultaneous, chronic treatment with the juice expressed from the crushed, whole, fresh pepper fruit, plus the mixture of 20mM methyl urea (MU) and sodium nitrite (SN), mixed with the animals' food. Three doses of pepper juice (12.5, 25, and 50%) were used. The background mutation rate given as spots per wing was 0.36 and 0.48 for ST and HB, respectively. Mutation frequencies produced by the MU and SN mixture was 1.73 (ST) and 26.46 (HB) mutations per wing. The poblano juice decreased the above rates between 40 and 80%, respectively. The experiments suggest that some compounds present in the green pepper may cause this antimutagenic effect by interfering with the nitrosation process. The role of the extract and one of its components, such as vitamin C, in the nitrosation process will be discussed.
P Ramirez-Victoria; J Guzman-Rincon; J J Espinosa-Aguirre; S Murillo-Romero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  496     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-11     Completed Date:  2001-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Facultad de Ciencias, Universidad Nacional Autónoma de México, México City, México.
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MeSH Terms
Antimutagenic Agents / metabolism,  pharmacology*
Capsicum / chemistry*,  metabolism
Dose-Response Relationship, Drug
Drosophila melanogaster / drug effects,  genetics,  metabolism
Methylurea Compounds / metabolism,  toxicity
Mutagenicity Tests
Mutagens / toxicity
Nitrates / metabolism,  toxicity
Nitrosation / drug effects*
Plant Extracts / metabolism,  pharmacology*
Plants, Medicinal*
Recombination, Genetic
Wing / drug effects,  growth & development
Reg. No./Substance:
0/Antimutagenic Agents; 0/Methylurea Compounds; 0/Mutagens; 0/Nitrates; 0/Plant Extracts; 598-50-5/methylurea; 7631-99-4/sodium nitrate

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