| Antimutagenic effect of one variety of green pepper (Capsicum spp.) and its possible interference with the nitrosation process. | |
| | |
MedLine Citation:
|
PMID: 11551479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is known that the poblano green pepper, a significant component in the Mexican diet, contains certain natural compounds such as chlorophyll, beta-carotene, and vitamins, which have antimutagenic and/or anticarcinogenic properties. Using the somatic mutation and recombination test in wing cells of Drosophila melanogaster, an extract of the poblano pepper (Capsicum spp.) was evaluated to determine its antimutagenic effect against the nitrosation process, simulating the process occurring in the human stomach caused by known food additives. Larvae of 72h old D. melanogaster of standard (ST) and high bioactivation (HB) crosses were exposed in a simultaneous, chronic treatment with the juice expressed from the crushed, whole, fresh pepper fruit, plus the mixture of 20mM methyl urea (MU) and sodium nitrite (SN), mixed with the animals' food. Three doses of pepper juice (12.5, 25, and 50%) were used. The background mutation rate given as spots per wing was 0.36 and 0.48 for ST and HB, respectively. Mutation frequencies produced by the MU and SN mixture was 1.73 (ST) and 26.46 (HB) mutations per wing. The poblano juice decreased the above rates between 40 and 80%, respectively. The experiments suggest that some compounds present in the green pepper may cause this antimutagenic effect by interfering with the nitrosation process. The role of the extract and one of its components, such as vitamin C, in the nitrosation process will be discussed. |
| | |
Authors:
|
P Ramirez-Victoria; J Guzman-Rincon; J J Espinosa-Aguirre; S Murillo-Romero |
Related Documents
:
|
9734739 - Serum retinol concentrations in children are affected by food sources of beta-carotene,... 18214019 - The bioavailability of (pro) vitamin a carotenoids and maximizing the contribution of h... 12076219 - Dietary intake of antioxidant nutrients and the risk of incident alzheimer disease in a... 2309649 - Questioning riboflavin recommendations on the basis of a survey in china. 3313139 - Inequalities in nutrition. 19838919 - Patterns of food and nutrient consumption in northern iran, a high-risk area for esopha... 11125879 - Deficits of masticatory movements caused by lesions in the orofacial somatosensory cort... 3572299 - Choice between sequences of fixed-ratio schedules: effects of ratio values and probabil... 12189589 - Leptin treatment during the neonatal period is associated with higher food intake and a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Mutation research Volume: 496 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2001-09-11 Completed Date: 2001-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 39-45 Citation Subset: IM |
Affiliation:
|
Facultad de Ciencias, Universidad Nacional Autónoma de México, México City, México. prvirri@ees.eesc.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antimutagenic Agents / metabolism, pharmacology* Capsicum / chemistry*, metabolism Diet Dose-Response Relationship, Drug Drosophila melanogaster / drug effects, genetics, metabolism Female Male Methylurea Compounds / metabolism, toxicity Mutagenicity Tests Mutagens / toxicity Mutation Nitrates / metabolism, toxicity Nitrosation / drug effects* Plant Extracts / metabolism, pharmacology* Plants, Medicinal* Recombination, Genetic Wing / drug effects, growth & development |
| Chemical | |
Reg. No./Substance:
|
0/Antimutagenic Agents; 0/Methylurea Compounds; 0/Mutagens; 0/Nitrates; 0/Plant Extracts; 598-50-5/methylurea; 7631-99-4/sodium nitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against...
Next Document: Protection against ultraviolet B- and C-induced DNA damage and skin carcinogenesis by the flowers of...