| Antimutagenic activity of chemical fractions isolated from a commercial soybean processing by-product. | |
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MedLine Citation:
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PMID: 10332809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Commercial products of agronomic crop plants may become a reliable and inexpensive source of phytonutrients, such as antimutagenic food supplements. We previously demonstrated that PCC, an ethanol extract of a commercial soybean processing by-product, was able to repress induced genomic DNA damage, whole cell clastogenicity, and point mutation in mammalian cells. In this paper we separated PCC into a series of chemically defined fractions and determined their ability to repress induced mutagenic damage in Chinese hamster lung cells, Chinese hamster ovary cells and human lymphocytes. Fraction PCC70 (PCC 70% methanol eluate) contained the flavonoids from PCC and daidzin and genistin repressed 2-acetoxyacetylaminofluorene (2AAAF)-induced DNA damage measured with single cell gel electrophoresis. Genistein, however, enhanced the genotoxic impact of 2AAAF. Fraction PCC100 (PCC 100% methanol eluate) had the greatest level of antigenotoxic activity against 2AAAF in CHO cells and repressed the genotoxic capacity of the dietary carcinogen 2-amino-3-methylimidazo-(4,5-f)quinoline (IQ) in human lymphocytes. These data indicate that commercial soybean products and by-products may be a source of chemoprotective food additives. |
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Authors:
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M J Plewa; E D Wagner; M A Berhow; A Conway; A L Rayburn; D Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Teratogenesis, carcinogenesis, and mutagenesis Volume: 19 ISSN: 0270-3211 ISO Abbreviation: Teratog., Carcinog. Mutagen. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-08-11 Completed Date: 1999-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100917 Medline TA: Teratog Carcinog Mutagen Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 121-35 Citation Subset: IM |
Affiliation:
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Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, USA. m-plewa@uiuc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimutagenic Agents / pharmacology* CHO Cells Cell Fractionation Cricetinae Dose-Response Relationship, Drug Flow Cytometry Food Handling* Humans Lymphocytes / drug effects Mutagenicity Tests Soybeans / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antimutagenic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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