Document Detail


Antimutagenic Effect of Aqueous Extract from Agaricus brasiliensis on Culture of Human Lymphocytes.
MedLine Citation:
PMID:  23289788     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The mushroom Agaricus brasiliensis (sun mushroom), native from the southeast of Brazil, is well known by its medicinal properties that include effects on diabetes, cholesterol levels, and osteoporosis. The antimutagenic effects of A. brasiliensis has been investigated recently and revealed some controversial results depending on the temperature by which the A. brasiliensis tea is obtained. In the present study, we evaluated the effect of the A. brasiliensis extract prepared in two different temperatures, 4°C and 25°C, on the doxorubicin-induced DNA strand breaks and chromosomal aberrations (CAs) in human lymphocytes. The results demonstrated that A. brasiliensis was able to reduce the DXR-induced DNA damage in both temperatures; however, the CA test was more sensitive to demonstrate a better reduction when the cells were treated with an extract obtained at 25°C. A. brasiliensis extract obtained in different temperatures exhibited antigenotoxic and anticlastogenic effects in human lymphocytes.
Authors:
Paula H Gameiro; José S Nascimento; Beatriz H G Rocha; Clause F B Piana; Raquel A Santos; Catarina S Takahashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-5
Journal Detail:
Title:  Journal of medicinal food     Volume:  -     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Department of Microbiology and Parasitology, Federal University of Pelotas , Pelotas, Rio Grande do Sul, Brazil .
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