| Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts. | |
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MedLine Citation:
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PMID: 20959614 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro-o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its fractions were more efficient against S9-dependent mutagen in pre-incubation mode of treatment as compared to direct-acting mutagens in both the strains. Methanol extract and its fractions also exhibited strong radical-scavenging potential. High-performance liquid chromatography (HPLC) analysis of methanol extract showed the presence of gallic acid, epicatechin, 7-hydroxycoumarin, and rutin. From the study, it could be concluded that antioxidative and antimutagenic activity of methanol extract and its fractions was related to the synergistic interactions among different chemical compounds. |
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Authors:
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Rajbir Kaur; Upendra Sharma; Bikram Singh; Saroj Arora |
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Publication Detail:
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Type: Journal Article Date: 2010-10-19 |
Journal Detail:
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Title: International journal of toxicology Volume: 30 ISSN: 1092-874X ISO Abbreviation: Int. J. Toxicol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 21-34 Citation Subset: IM |
Affiliation:
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Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India Email: dr.sarojarora@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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