Document Detail

Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts.
MedLine Citation:
PMID:  20959614     Owner:  NLM     Status:  In-Data-Review    
The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro-o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its fractions were more efficient against S9-dependent mutagen in pre-incubation mode of treatment as compared to direct-acting mutagens in both the strains. Methanol extract and its fractions also exhibited strong radical-scavenging potential. High-performance liquid chromatography (HPLC) analysis of methanol extract showed the presence of gallic acid, epicatechin, 7-hydroxycoumarin, and rutin. From the study, it could be concluded that antioxidative and antimutagenic activity of methanol extract and its fractions was related to the synergistic interactions among different chemical compounds.
Rajbir Kaur; Upendra Sharma; Bikram Singh; Saroj Arora
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Publication Detail:
Type:  Journal Article     Date:  2010-10-19
Journal Detail:
Title:  International journal of toxicology     Volume:  30     ISSN:  1092-874X     ISO Abbreviation:  Int. J. Toxicol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708436     Medline TA:  Int J Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-34     Citation Subset:  IM    
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India Email:
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