Document Detail

Antimitotics in cancer chemotherapy.
MedLine Citation:
PMID:  1544129     Owner:  NLM     Status:  MEDLINE    
Many agents used in cancer chemotherapy act on a specific phase of the cell cycle and are classified as cell cycle-specific. Some of these cell cycle-specific drugs, the antimitotics, interact with tubulin, the major protein of mitotic spindles, and cause metaphase arrest, thus halting mitosis. Understanding the dynamic processes involved in tubulin polymerization/depolymerization and how chemotherapeutic agents disrupt these processes is fundamental to understanding and anticipating common adverse effects and planning nursing interventions.
S Lobert; J J Correia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cancer nursing     Volume:  15     ISSN:  0162-220X     ISO Abbreviation:  Cancer Nurs     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805358     Medline TA:  Cancer Nurs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  22-33     Citation Subset:  IM; N    
University of Mississippi Medical Center School of Nursing, Jackson 39216.
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MeSH Terms
Antineoplastic Agents / adverse effects,  pharmacology,  therapeutic use*
Clinical Trials as Topic
Neoplasms / drug therapy*,  nursing
Oncologic Nursing / methods
Patient Care Planning
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents

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