Document Detail


Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).
MedLine Citation:
PMID:  8157136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acyclic nucleotide analogues, HPMPC and PMEA, differ in their in vitro effect on the genetic material of eukaryotic cells. While HPMPC exerts a cytostatic effect on eukaryotic cells in vitro, PMEA has a genotoxic activity. These results correspond with the mode of embryotoxic action of these compounds: HPMPC exhibits a general embryolethal effect, whereas PMEA is apparently teratogenic and interacts with the mutant allele producing preaxial polydactyly of the hind limbs.
Authors:
V Bílá; B Otová; R Jelínek; M Sladká; B Mejsnarová; A Holý; V Kren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia biologica     Volume:  39     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  1993  
Date Detail:
Created Date:  1994-05-16     Completed Date:  1994-05-16     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  150-61     Citation Subset:  IM    
Affiliation:
Department of Biology, 1st Faculty of Medicine, Charles University, Praha.
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MeSH Terms
Descriptor/Qualifier:
Adenine / analogs & derivatives*,  toxicity
Animals
Antiviral Agents / toxicity*
Cell Line
Cells, Cultured
Chick Embryo
Cytosine / analogs & derivatives*,  toxicity
Female
Fibroblasts / cytology,  drug effects*
Humans
Lung / cytology,  drug effects*
Male
Mitosis
Organophosphonates*
Organophosphorus Compounds / toxicity*
Polydactyly / chemically induced
Rats
Rats, Inbred BN
Rats, Inbred Lew
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Organophosphonates; 0/Organophosphorus Compounds; 6GQP90I798/adefovir; 71-30-7/Cytosine; 73-24-5/Adenine; JIL713Q00N/cidofovir

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