Document Detail


Antimitotic and antifungal C-3/C-3''-biflavanones from Stellera chamaejasme.
MedLine Citation:
PMID:  15997133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new C-3/C-3'' biflavanones, chamaejasmenin D (1) and isochamaejasmenin B (2), were isolated from the roots of Stellera chamaejasme, together with five known biflavanones, chamaejasmenin A (3), chamaejasmenin B (4), neochamaejasmin A (5), sikokianin A (6), and chamaejasmenin C (7). Their structures were elucidated by spectroscopic methods, including 2D NMR techniques. Among these compounds, 1-3 demonstrated potent antimitotic and antifungal activity with minimum inhibitory concentration (MIC) values of 6.25, 6.25, and 3.12 microg/ml, respectively.
Authors:
Guohong Yang; Zhixin Liao; Zhiyong Xu; Huiping Zhang; Daofeng Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  53     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-05     Completed Date:  2005-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  776-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Flavones / chemistry,  isolation & purification*,  pharmacology
Mitosis / drug effects*
Spectrum Analysis
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Flavones

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