Document Detail

Antimitotic Activity on Sea Urchin Embryonic Cells of Seven Antiparasitic Morita-Baylis-Hillman Adducts: A Potential New Class Of Anticancer Drugs.
MedLine Citation:
PMID:  22830498     Owner:  NLM     Status:  Publisher    
In the present work we described improvements in the 1-7 antiparasitic Morita-Baylis-Hillman Adducts synthesis and their antimitotic activity on sea urchin embryonic cells. The 2-[Hydroxy(2-nitrophenyl)methyl]acrylonitrile (1) and 2-[Hydroxy(4-bromophenyl) methyl]acrylonitrile (4) were the most effective compounds to block the progression to embryonic morula stage (EC50 = 75.8 μM and 72.6μM, respectively). Compounds 1 and 4 were also effective in blocking the first cell division but to a lesser extent. The 2-[Hydroxy(pyridin-4-yl)methyl]acrylonitrile (7) exhibited a strong inhibition of cell divisions and progression to the first cleavage and morula stage. Fluorescent dye extrusion assay suggests that these adducts are not ABC protein substrates, which confers an additional interest in these new class of potential anticancer drugs.
Jocelmo C A Leite; Claudio G L Junior; Fábio P L Silva; Suervy C O Sousa; Mário L A A Vasconcellos; Luis F Marques-Santos
Related Documents :
7768638 - Retinoic acid induced death of ovarian carcinoma cells correlates with c-myc stimulation.
21517028 - Comparative cytotoxicity of gambierol versus other marine neurotoxins.
19232378 - Expression analysis of green fluorescent protein in retinal neurons of four transgenic ...
9363748 - Cell-growth regulation of the hamster dihydrofolate reductase gene promoter by transcri...
3360748 - Scanning electron microscope studies of agrobacterium tumefaciens attachment to zea may...
7250638 - Inhibition of hcl secretion and the effects on ultrastructure and electrical resistance...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  Medicinal chemistry (Shariqah (United Arab Emirates))     Volume:  -     ISSN:  1875-6638     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240303     Medline TA:  Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratório de Síntese Orgânica Medicinal da Paraíba (LASOM-PB)-Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa, PB, Brazil;; marques@
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines.
Next Document:  A cross-sectional study of pandemic influenza health literacy and the effect of a public health camp...