| Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 17919234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Primary biliary cirrhosis (PBC) is characterised by the presence of immunoglobulin (Ig) G antimitochondrial antibodies (AMA), which are routinely detected by indirect immunofluorescence (IFL) using composite rodent tissue substrate. The IgG subclass distribution and clinical significance of IFL-detected AMA in patients with PBC have not been previously studied in detail. METHODS: We have examined IgG subclass-specific AMA detected by IFL on rodent liver, kidney and stomach tissue substrate using affinity-purified IgG subclass monospecific antisera as revealing reagents in 95 AMA-positive PBC patients from Greece. RESULTS: AMA of any of the IgG1, IgG2 or IgG3 subclasses were present in 89/95 (93.7%) patients. Among those 89, 55 (61.8%) had IgG1, 2, 3 AMA positivity; eight (9%) had IgG1, 2; seven (7.9%) had IgG2, 3; eight (9%) had IgG1, 3; nine (10.1%) had IgG1 subclass and two (2.2%) single IgG3 AMA reactivity. IgG4 AMA was absent. IgG3 titres were higher than IgG2 and IgG1 (P<0.001) and IgG1 higher than IgG2 (P<0.001). IgG3 AMA-positive patients had a histologically more advanced disease (P<0.01) and were more frequently cirrhotic compared with those who were negative (P<0.01). There was a positive correlation between AMA IgG3 titre and Mayo risk score (r=0.55, P=0.009, Spearman's correlation). CONCLUSIONS: Our findings suggest that AMA are not restricted to a specific IgG subclass. AMA of the IgG3 subclass are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage. |
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Authors:
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Eirini I Rigopoulou; Edward T Davies; Dimitrios-Petrou Bogdanos; Christos Liaskos; Maria Mytilinaiou; George K Koukoulis; George N Dalekos; Diego Vergani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 27 ISSN: 1478-3223 ISO Abbreviation: Liver Int. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-08 Completed Date: 2008-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160857 Medline TA: Liver Int Country: England |
Other Details:
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Languages: eng Pagination: 1226-31 Citation Subset: IM |
Affiliation:
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Academic Liver Unit and Research Laboratory of Internal Medicine, Department of Medicine, University of Thessaly, Larissa, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Autoantibodies / blood* Disease Progression Female Fluorescent Antibody Technique, Indirect Humans Immunoglobulin Isotypes / blood* Liver Cirrhosis, Biliary / blood, diagnosis* Male Middle Aged Mitochondria, Liver / immunology* Predictive Value of Tests |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulin Isotypes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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