Document Detail

Antimigration property of a newly designed covered metal stent for esophageal stricture: an in vivo animal study.
MedLine Citation:
PMID:  21704813     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Covered self-expandable metal stents (SEMSs) are associated with a higher migration rate than uncovered SEMSs.
OBJECTIVE: The antimigration property of a novel covered SEMS was investigated in a canine esophageal stricture model.
DESIGN: The new stent (80 mm in length, 20 or 24 mm in diameter) has multiple protuberances on its body that were designed to be separated from the inner silicone membrane so that they could be embedded into the mucosa after deployment. Twenty-two beagle dogs were subjected to circumferential EMR in the middle esophagus for stricture formation. After 2 weeks, conventional covered stents were inserted in a control group (n = 11), and the newly designed covered SEMSs were inserted in a study group (n = 11).
SETTING: Animal laboratory.
INTERVENTIONS: Circumferential EMR of the middle esophagus for stricture formation, followed by endoscopic placement of a conventional or newly designed stent.
MAIN OUTCOME MEASUREMENTS: Migration, complications, survival, and esophageal histopathology.
RESULTS: There was no significant difference in the diameter of the esophageal stricture between the control and study groups (10 mm vs 11 mm, P = .52). Within 3 days, all stents in the control group had migrated, whereas 6 had migrated in the study group (100% vs 55%, P = .035). There were no significant complications directly associated with stent insertion.
LIMITATIONS: Complications, survival, and esophageal histopathology could not be compared because all of the conventional stents migrated in the control group within 3 days.
CONCLUSIONS: The newly designed covered SEMS is more resistant to migration than the conventional covered SEMS.
Jeong-Seon Ji; Bo-In Lee; Hyung-Keun Kim; Young-Seok Cho; Hwang Choi; Byung-Wook Kim; Sang-Woo Kim; Sung-Soo Kim; Hiun-Suk Chae; Kyu-Yong Choi; Lee-So Maeng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  74     ISSN:  1097-6779     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
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