Document Detail

Antimicrobial susceptibility testing of dermatophytes--comparison of the agar macrodilution and broth microdilution tests.
MedLine Citation:
PMID:  9444406     Owner:  NLM     Status:  MEDLINE    
Fifty dermatophyte strains, recently obtained from clinical material, belonging to 4 different species were examined for their susceptibility to 5 systemic or topical antimycotic agents using both an agar macrodilution and a broth microdilution test. Antimycotics compared were griseofulvin, itraconazole, sertaconazole, terbinafine and ciclopiroxolamine. A comparison of the minimum inhibitory concentrations (MIC) clearly showed differences between the two test methods applied. For all 5 antimycotics, MIC data were three- to seventy-fold lower in the microdilution test system. These differences, depending on the test method, have to be taken into account when comparing MIC data in the literature or when relating the in vitro data to the tissue concentrations determined in vivo.
M Niewerth; V Splanemann; H C Korting; J Ring; D Abeck
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  44     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-02-27     Completed Date:  1998-02-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Hautklinik des Universitätskrankenhauses Eppendorf, Hamburg, Germany.
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MeSH Terms
Antifungal Agents / pharmacology*
Arthrodermataceae / drug effects*
Colony Count, Microbial
Griseofulvin / pharmacology
Imidazoles / pharmacology
Itraconazole / pharmacology
Microbial Sensitivity Tests / methods*
Naphthalenes / pharmacology
Pyridones / pharmacology
Thiophenes / pharmacology
Reg. No./Substance:
0/Antifungal Agents; 0/Imidazoles; 0/Naphthalenes; 0/Pyridones; 0/Thiophenes; 126-07-8/Griseofulvin; 29342-05-0/ciclopirox; 84625-61-6/Itraconazole; 91161-71-6/terbinafine; 99592-32-2/sertaconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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