Document Detail

Antimicrobial susceptibilities and beta-lactamase production of Hong Kong isolates of gastroenteric salmonellae and Salmonella typhi.
MedLine Citation:
PMID:  1816184     Owner:  NLM     Status:  MEDLINE    
We examined the in-vitro antibiotic susceptibility of 760 gastroenteric salmonellae and 36 strains of Salmonella typhi isolated in Hong Kong between 1985 and 1988. S. typhi remained susceptible to all the antibiotics tested except for one isolate resistant to chloramphenicol, another to kanamycin and co-trimoxazole, and a third to nalidixic acid. In contrast, resistance and multiple resistance has increased significantly in gastroenteric salmonellae over the last ten years. Seventeen percent were resistant to ampicillin, 61% to tetracycline, 23% to chloramphenicol and 8% to gentamicin. Many ampicillin-resistant strains remained resistant to ampicillin even in the presence of sulbactam (69%) or clavulanic acid (25%). More than 50% of isolates were resistant to two or more antibiotics and one isolate was resistant to eleven. Ampicillin-resistance was usually due to the production of TEM-1 or OXA-1 beta-lactamases but a few isolates produced AER-1, PSE-1 or PSE-2. Genetic determinants for these enzymes were usually borne on plasmids ranging in size from 2 to 143.7 Md but half of the OXA-1 genes were chromosomally located.
J M Ling; G M Zhou; T H Woo; G L French
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  28     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-30     Completed Date:  1992-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  877-85     Citation Subset:  IM    
Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
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MeSH Terms
Ampicillin Resistance
Anti-Bacterial Agents / pharmacology*
Chloramphenicol Resistance
Drug Resistance, Microbial
Hong Kong
Microbial Sensitivity Tests
Plasmids / genetics
Salmonella / drug effects*,  enzymology
Salmonella paratyphi B / drug effects,  enzymology
Salmonella paratyphi C / drug effects,  enzymology
Salmonella typhi / drug effects*,  enzymology
Species Specificity
beta-Lactamases / biosynthesis*
Reg. No./Substance:
0/Anti-Bacterial Agents; EC
Comment In:
J Antimicrob Chemother. 1994 May;33(5):1055-6   [PMID:  8089054 ]

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