Document Detail

Antimicrobial resistance in typhoidal and nontyphoidal salmonellae.
MedLine Citation:
PMID:  18725804     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Increasing occurrence of antimicrobial resistance in both typhoidal and nontyphoidal salmonellae is a major public health problem. Recent studies documenting the occurrence and types of resistance, with particular reference to quinolones and extended spectrum cephalosporins, and new approaches to treatment are reviewed.
RECENT FINDINGS: Community and hospital-based studies in different Asian and African countries show widely variable rates of resistance in Salmonella enterica serovars Typhi and Paratyphi A. Occurrence of multidrug resistance has declined in some areas, but the incidence of decreased ciprofloxacin susceptibility has reached high levels, particularly in the Indian subcontinent, and isolates with full resistance to this antimicrobial are increasingly reported. Similar variability in resistance rates occurs among nontyphoidal salmonellae, with variation between serovars and by region. There are reports of plasmid-mediated qnr genes and a variety of extended spectrum cephalosporin resistance genes in nontyphoidal serovars. Two randomized controlled trials report gatifloxacin as a potential treatment option in enteric fever caused by multidrug-resistant isolates with decreased ciprofloxacin susceptibility.
SUMMARY: Patterns of resistance in Salmonella are constantly changing. Continual surveillance of resistance levels is critical for clinicians to keep abreast of treatment options, but it is often lacking in resource-poor regions of the world with the highest disease burden.
Christopher M Parry; E J Threlfall
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  21     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-11-05     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
Division of Medical Microbiology and Genitourinary Medicine and The National Centre for Zoonosis Research, Faculty of Medicine, University of Liverpool, Liverpool, UK.
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MeSH Terms
Anti-Infective Agents / therapeutic use*
Drug Resistance, Microbial*
Salmonella Infections / drug therapy*,  microbiology*
Salmonella enterica / drug effects,  genetics
Salmonella typhi / drug effects,  isolation & purification
Typhoid Fever / drug therapy*,  microbiology
Reg. No./Substance:
0/Anti-Infective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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