| Antimicrobial resistance among invasive Haemophilus influenzae strains: results of a Brazilian study carried out from 1996 through 2000. | |
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MedLine Citation:
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PMID: 12426628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 1712 strains of Haemophilus influenzae isolated from patients with invasive diseases were obtained from ten Brazilian states from 1996 to 2000. beta-Lactamase production was assessed and the minimum inhibitory concentrations (MIC) of ampicillin, chloramphenicol, ceftriaxone and rifampin were determined using a method for broth microdilution of Haemophilus test medium. The prevalence of strains producing beta-lactamase ranged from 6.6 to 57.7%, with an overall prevalence of 18.4%. High frequency of beta-lactamase-mediated ampicillin resistance was observed in Distrito Federal (25%), São Paulo (21.7%) and Paraná (18.5%). Of the 1712 strains analyzed, none was beta-lactamase negative, ampicillin resistant. A total of 16.8% of the strains were resistant to chloramphenicol, and 13.8% of these also presented resistance to ampicillin, and only 3.0% were resistant to chloramphenicol alone. All strains were susceptible to ceftriaxone and rifampin and the MIC90 were 0.015 micro g/ml and 0.25 micro g/ml, respectively. Ceftriaxone is the drug of choice for empirical treatment of bacterial meningitis in pediatric patients who have not been screened for drug susceptibility. The emergence of drug resistance is a serious challenge for the management of invasive H. influenzae disease, which emphasizes the fundamental role of laboratory-based surveillance for antimicrobial resistance. |
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Authors:
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S T Casagrande; I M Landgraf; A M M Kobata; R C Zanella; S Bokermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 35 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-11 Completed Date: 2003-04-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 1293-300 Citation Subset: IM |
Affiliation:
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Departamento de Bacteriologia, Instituto Adolfo Lutz, São Paulo, SP, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ampicillin Resistance Anti-Bacterial Agents / pharmacology* Brazil Ceftriaxone / pharmacology Child Chloramphenicol Resistance Drug Resistance, Bacterial Haemophilus influenzae / drug effects*, enzymology, isolation & purification Humans Meningitis, Haemophilus / microbiology* Microbial Sensitivity Tests Rifampin / pharmacology beta-Lactamases / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 13292-46-1/Rifampin; 73384-59-5/Ceftriaxone; EC 3.5.2.6/beta-Lactamases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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