Document Detail

Antimicrobial prophylaxis in laparoscopic gynecologic surgery: a prospective randomized study comparing amoxicillin-clavulanic acid with cefazolin.
MedLine Citation:
PMID:  14998083     Owner:  NLM     Status:  MEDLINE    
Numerous studies have been published in recent years about antimicrobial prophylaxis in gynecologic surgery, but the optimal drug and schedule for the different surgical procedures is still a matter of debate. The aim of the present study was to compare two ultra-short term antimicrobial prophylaxis regimens (amoxicillin-clavulanic acid and cefazolin) in preventing infections following laparoscopic gynecologic operations. Three hundred sixty women hospitalized for a laparoscopic gynecologic surgery procedure were included in the study between January 1999, and December 2001. Patients were randomly allocated to receive amoxicillin-clavulanic acid (2.2 g) [Group A] or cefazolin (2 g) [Group B] as a single dose 30 minutes before surgery. Each patient was assessed daily until discharge to evidence febrile status and the presence of infections at the operative site, urinary tract and respiratory tract. In the amoxicillin-clavulanic acid (Group A) and cefazolin (Group B) groups, overall 164 and 172 patients, respectively, were evaluable for prophylactic efficacy at hospital discharge. Infectious complications were infrequent in both groups with febrile morbidity occurring in only one patient (0.6%) in the amoxicillin-clavulanic group. No sign of infections at the surgical site, urinary tract and respiratory tract was observed in either group. No death due to sepsis was recorded. It is concluded that ultra-short term prophylaxis with both amoxicillin-clavulanic acid and cefazolin is safe and effective in elective laparoscopic gynecologic surgery.
G Cormio; S Bettocchi; O Ceci; L Nappi; F Di Fazio; C Cacciapuoti; L Selvaggi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  15     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-03-04     Completed Date:  2004-04-15     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  574-8     Citation Subset:  IM    
Department of General and Specialist Surgical Sciences, Section of Obstetrics and Gynecology, University of Bari, Italy.
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MeSH Terms
Amoxicillin-Potassium Clavulanate Combination / administration & dosage*
Antibiotic Prophylaxis*
Cefazolin / administration & dosage*
Drug Administration Schedule
Follow-Up Studies
Genital Diseases, Female / diagnosis,  surgery
Laparoscopy / methods*
Length of Stay
Middle Aged
Postoperative Complications / prevention & control
Preoperative Care / methods
Prospective Studies
Reference Values
Risk Assessment
Treatment Outcome
Reg. No./Substance:
25953-19-9/Cefazolin; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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