Document Detail

Antimicrobial prophylaxis for arthroplasty and total joint replacement: discussion and review of published clinical trials.
MedLine Citation:
PMID:  2052470     Owner:  NLM     Status:  MEDLINE    
Cephalosporins are often administered to prevent infections that can follow total joint replacements (TJR) and other arthroplastic procedures. However, recommendations contained within published guidelines and review articles vary greatly from those given by the manufacturer in product information circulars. Similarly, the results of published clinical trials vary substantially with regard to the choice of cephalosporin, the dose and dosing interval, and the duration of administration that should be used for antimicrobial prophylaxis in patients undergoing clean orthopedic procedures. Well-designed clinical trials provide data concerning the appropriate use of cephalosporins for preventing infections that may follow TJR or joint arthroplasty.
A F Heath
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  11     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-19     Completed Date:  1991-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Drug Information Services, Glaxo Inc., Research Triangle Park, North Carolina 27709.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Bacterial Infections / microbiology,  prevention & control*
Clinical Trials as Topic
Joint Prosthesis / adverse effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Lactams

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