| Antimicrobial property, antioxidant capacity, and cytotoxicity of essential oil from cumin produced in Iran. | |
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MedLine Citation:
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PMID: 20492235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cumin (Cuminum cyminum) is one of the commonly used spices in food preparations. It is also used in traditional medicine as a stimulant, a carminative, and an astringent. In this study, we characterized the antimicrobial, antioxidant, and cytotoxic activities of cumin. E. coli, S. aureus, and S. faecalis were sensitive to various oil dilutions. The total phenol content of the essential oil was estimated to be 33.43 microg GAE/mg of the oil. The oil showed higher antioxidant activity compared with that of BHT and BHA. The cumin essential oil exhibited a dose-dependent scavenging of DPPH radicals and 5.4 microg of the oil was sufficient to scavenge 50% of DPPH radicals/mL. At a concentration of 0.1 microL/mL, oil destructed Hela cells by 79%. The antioxidant activity of cumin essential oil might contribute to its cytotoxic activity. Acute and subchronic toxicity was studied in a 30-d oral toxicity study by administration to Wistar rats of the essential oil. A 17.38% decrease in WBCs count, and 25.77%, 14.24%, and 108.81% increase in hemoglobin concentration, hematocrit, and platelet count, respectively, were noted. LDL/HDL ratio was reduced to half, which adds to the nutritional effects of cumin. Thus, cumin with a high phenolic content and good antioxidant activity can be supplemented for both nutritional purposes and preservation of foods. |
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Authors:
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Tolou Allahghadri; Iraj Rasooli; Parviz Owlia; Mohammadreza Jalali Nadooshan; Tooba Ghazanfari; Massoud Taghizadeh; Shakiba Darvish Alipoor Astaneh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of food science Volume: 75 ISSN: 1750-3841 ISO Abbreviation: J. Food Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: United States |
Other Details:
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Languages: eng Pagination: H54-61 Citation Subset: IM |
Affiliation:
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Dept. of Biology, Shahed Univ., Tehran-Qom Express Way, Opposite Imam Khomeini's shrine, Tehran 3319118651, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / blood, chemistry, pharmacology* Antineoplastic Agents / blood, chemistry, pharmacology* Antioxidants / chemistry, pharmacology* Blood Cells / drug effects Cuminum / chemistry* Dose-Response Relationship, Drug Female Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Hemoglobins / drug effects Humans Iran Male Oxidation-Reduction / drug effects Plant Oils / chemistry, pharmacology* Rats Rats, Wistar Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antineoplastic Agents; 0/Antioxidants; 0/Hemoglobins; 0/Plant Oils |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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