Document Detail


Antimicrobial properties of Anopheles albimanus pericardial cells.
MedLine Citation:
PMID:  23229355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insect pericardial cells (PCs) are strategically located along the dorsal vessel where they encounter a high hemolymph flow enabling them to undertake their osmoregulatory, detoxifying, and scavenging functions. In this location, PCs also encounter foreign molecules and microorganisms. The response of PCs of the mosquito Anopheles albimanus, one of the most important Plasmodium vivax vectors in Mexico and Latin America, to Saccharomyces cerevisiae was analyzed by using biochemical, cellular, ultrastructural, and bioinformatics approaches. Immune gene transcripts were identified in the PC transcriptome of A. albimanus. PCs responded to the presence of yeast and zymosan with increased lysosomal and phosphatase activities and produced lytic activity against bacteria. Our results indicate that mosquito PCs play a key role in the neutralization and elimination of pathogens.
Authors:
Salvador Hernández-Martínez; Humberto Lanz-Mendoza; Jesús Martínez-Barnetche; Mario H Rodríguez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-16
Journal Detail:
Title:  Cell and tissue research     Volume:  351     ISSN:  1432-0878     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-05     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  127-37     Citation Subset:  IM    
Affiliation:
Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Col. Sta. María Ahuacatitlan, Cuernavaca, Morelos, México. shernandez@insp.mx
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / metabolism
Animals
Anopheles / cytology*
Anti-Infective Agents / metabolism*
Female
Immunity / genetics
Lysosomes / metabolism
Pericardium / cytology*,  immunology,  microbiology,  ultrastructure
RNA, Messenger / genetics,  metabolism
Saccharomyces cerevisiae / physiology
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/RNA, Messenger; EC 3.1.3.2/Acid Phosphatase
Comments/Corrections

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