Document Detail

Antimicrobial prenylated dihydrochalcones from Eriosema glomerata.
MedLine Citation:
PMID:  18203062     Owner:  NLM     Status:  MEDLINE    
Two new natural dihydrochalcones exhibiting antimicrobial properties together with six known compounds were isolated from the Cameroonian medicinal plant Eriosema glomerata. The structures of the new dihydrochalcones were elucidated as 2',4'-dihydroxy-4-methoxy-3'-( gamma, gamma-dimethylallyl)dihydrochalcone and 2',4'-dihydroxy-3'-( gamma, gamma-dimethylallyl)dihydrochalcone by detailed spectroscopic analysis. The two new dihydrochalcones, named erioschalcones A ( 1) and B ( 2), demonstrated significant inhibitory activity against the microbial strains Bacillus megaterium, Escherichia coli, Chlorella fusca and Microbotryum violaceum.
Maurice D Awouafack; Simeon F Kouam; Hidayat Hussain; Dieudonne Ngamga; Pierre Tane; Barbara Schulz; Ivan R Green; Karsten Krohn
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-18
Journal Detail:
Title:  Planta medica     Volume:  74     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  50-4     Citation Subset:  IM    
Department of Chemistry, University of Dschang, Dschang, Cameroon.
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MeSH Terms
Algae, Green / drug effects
Anti-Infective Agents / administration & dosage,  pharmacology*,  therapeutic use
Chalcones / administration & dosage,  pharmacology,  therapeutic use
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Mitosporic Fungi / drug effects
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Anti-Infective Agents; 0/Chalcones; 0/Plant Extracts; 1083-30-3/dihydrochalcone

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